$100k Drug Discovery Grant – November 2017

November, 2017 – Identifying Inhibitors for the Management of Recurrent and/or Progressive Ewing Sarcoma and Osteosarcoma

This is the 2nd research grant supplied by Noah’s Bandage Project to Dr. Glen Samuel at Children’s Mercy Hospital in Kansas City.  In this study, Dr. Samuel and his team are investigating improvements to the therapeutic options available for pediatric patients diagnosed with recurrent and/or progressive Ewings Sarcoma and Osetosarcoma (bone cancers).  Specifically, they are focusing in on the Kinesin motor proteins KIF11, KIF15 and TPX2, which are key contributors to Mitosis (the process by which a single cancer cell divides to become two).  They are going to be testing four (4) compounds, in correlation with the KIF11 inhibitor, Ispinesib, that will identify the specific compound that inhibits these Kinesin motor proteins and ultimately results in cancer cell death.  This will allow for complete tumor cell death and/or stall tumor growth thereby increasing the ability to have better localized treatment (surgical resection +/- radiotherapy) in progressive or recurrent Ewing sarcoma and Osteosarcoma patients.